Hepatitis B virus reactivation
Conditions
Interventions
Entecavir group:Administration of Entecavir
Tenofovir fumarate group:Administration of Tenofovir disoproxil fumarate
Tenofovir alafenamide group:Administration of Tenofovir alafenamide
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Female patients aged over 18 and under 70 years; (2) Positive for HBsAg as indicated by hepatitis B surface antigen test (HBV two-phase test); (3) Histologically diagnosed breast cancer, with indications for adjuvant chemotherapy or neoadjuvant chemotherapy; (4) Subjects voluntarily participate in this study, sign informed consent, have good compliance, and cooperate with follow-up.
Exclusion criteria
Exclusion criteria: (1) Creatinine clearance was less than 50ml/min, ALT or AST was 10 times higher than the upper limit of normal, white blood cells <=3.5*10^9/L, platelets <=75*10^9/L, hemoglobin less than 10g/dl, albumin less than 3g/dl, total bilirubin greater than 2.5 times the upper limit of normal, The INR is 1.5 times greater than the upper limit of normal. (2) signs of decompensation of cirrhosis (Child-Pugh score B, C) or complicating hepatocellular carcinoma, alcoholic liver disease, autoimmune liver disease, hereditary liver disease, HIV, hepatitis C virus or hepatitis D virus infection; (3) Received chemotherapy or antiviral treatment within the last 1 year; (4) Pregnant and lactating women or those who have a history of psychotropic drug abuse and cannot quit or have mental disorders; (5) Patients who have not completed the established chemotherapy regimen or whose data is incomplete; (6) Patients who are not willing to accept the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatitis B virus DNA;C-reactive protein;Dilution and quantification of hepatitis B surface antigen;ß 2-microglobulin (urine);ß 2-microglobulin (blood);Determination of urinary a1 microglobulin;Osteocalcin;Special sequences of ß -collagen;Total type I collagen amino-terminal prolonging peptide;Cystatin;Ferritin;25-hydroxyvitamin D;Parathyroid hormone;Color Doppler ultrasound elastography of the liver;Total bilirubin;Direct bilirubin;Total protein;Albumin;Prealbumin;Alanine aminotransferase;Aspartate aminotransferase;Alkaline phosphatase;? -glutamyl aminotransferase;Cholinesterase;Total bile acid;Urea;Serum creatinine;Blood uric acid;Glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin (fasting);Glycosylated hemoglobin; | — |
Countries
China
Contacts
Public ContactLi Dan
Fujian Medical University Union Hospital
Outcome results
None listed