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Effects of eyelid-warming combined with meibomian expression at different frequencies on meibomian function in patients with moderate-to-severe meibomian gland dysfunction-associated dry eye

Effects of eyelid-warming combined with meibomian expression at different frequencies on meibomian function in patients with moderate-to-severe meibomian gland dysfunction-associated dry eye

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101373
Enrollment
Unknown
Registered
2025-04-24
Start date
2025-05-20
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Meibomian gland dysfunction

Interventions

Control group:Eyelid-warming combined with meibomian gland expression once a week
Experimental group:Eyelid-warming combined with meibomian gland expression fortnightly

Sponsors

Xi 'an First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age >=18 years old and =1/3 5. OSDI>13 6. Subjects and their guardians can understand the content of this study and voluntarily sign.

Exclusion criteria

Exclusion criteria: 1.Severe systemic diseases such as hypertension, diabetes mellitus, rheumatological and immunological diseases. 2.Patients with acute ocular inflammation and infection. 3.Ocular surgery or ocular trauma within six months, or the presence of developmental abnormalities. 4.Those who are pregnant, breastfeeding or planning to have children. 5.Special working environments such as high heat, dryness, etc. 6.Those deemed unsuitable for enrolment by the investigator.

Design outcomes

Primary

MeasureTime frame
Morphological parameters of the meibomian gland;

Secondary

MeasureTime frame
Dropout of meibomian gland;Ocular surface disease index;Meibomian glands yielding secretion score;Adverse event;Tear meniscus height;Non-invasive tearfilm break-up time;Eye dryness score;

Countries

China

Contacts

Public ContactXiao Xianghua

Xi 'an First Hospital

xianghuaxiao@yeah.net+86 29 87630869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026