Infectious disease
Conditions
Interventions
Group 1:None
Group 2:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Part 1: (1) Age> 18 years old; (2) The patients met the indications and dosage of cefoperazone/sulbactam instructions; (3) The course of treatment of cefoperazone/sulbactam >= 3 days; (4) Complete clinical data, blood and liver function biochemical examination indexes and coagulation function test data before and after cefoperazone/sulbactam treatment; (5) The coagulation function is normal and there is no bleeding symptom before medication. Part 2: (1) Age> 18 years old; (2) The course of treatment of target antimicrobial drugs (cefoperazone/sulbactam, tigecycline, vancomycin) >= 3 days; (3) The platelet count was normal and there were no bleeding symptoms before medication.
Exclusion criteria
Exclusion criteria: Part 1:(1) Patients with incomplete clinical and laboratory data; (2) Patients with comorbid hematological diseases; (3) Patients with pre - existing coagulation abnormalities before the use of cefoperazone/sulbactam; (4) Patients without coagulation function monitoring before and after treatment. Part 2:(1) Patients with comorbid hematological diseases; (2) Patients with pre - existing coagulation abnormalities before the use of target antibacterial drugs; (3) Patients without platelet count monitoring before and after treatment; (4) Patients with concomitant use of other drugs that can affect coagulation function, such as linezolid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| safety; | — |
Countries
China
Contacts
Public ContactZHU YUANCHAO
Beijing Hospital
Outcome results
None listed