Postoperative pain
Conditions
Interventions
Control group:Isovolemic saline was administered, and the infusion pattern was consistent with the other groups
Dexmedetomidine group:Intravenous continuous infusion of dexmedetomidine (rate 0.5 micrograms/kg/hour)
Esketamine group:Intravenous bolus loading dose of esketamine (0.25 mg/kg) was maintained at a rate of 0.12 mg/kg/h
Esketamine compound dexmedetomidine group:An intravenous bolus of esketamine (0.25 mg/kg) was administered, followed by continuous infusions of esketamine and dexmedetomidine at a rate of 0.12 mg/kg/h
Sponsors
Shengli Oilfield Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. 18 years old<= age <= 70 years old; 2. 18.0<BMI<28.0; 3. ASA classification is I.~III.; 4. Planned partial lung resection under tracheal intubation under general anesthesia, including: pulmonary wedgectomy, lung segmentectomy, and lobectomy. 5. Signed informed consent; 6. Receiving postoperative intravenous self-controlled analgesia;
Exclusion criteria
Exclusion criteria: 1. Patients who have contraindications to the use of esketamine before surgery, such as glaucoma, hyperthyroidism, intracranial hypertension, large arteries, etc.; 2. Patients with contraindications to the use of dexmedetomidine before surgery, such as patients with severe bradycardia, atrioventricular block of grade II or above, and sick sinus syndrome; 3. Patients with contraindications to the use of non-steroidal drugs before surgery, such as history of NSAIDs allergy, asthma and peptic ulcer; 4. Patients with preoperative systolic blood pressure >= 180 or = 110 or <= 60 mmHg; 5. Patients with severe cardiovascular and cerebrovascular diseases and liver and kidney insufficiency before surgery; 6. Patients with records of sedative or analgesic drug use within 72 hours before surgery; 7. Patients who have previously undergone partial lung resection; 8. Patients with hearing impairment, dyslexia, difficulty in communicating the sulcus, and inability to cooperate with the completion of postoperative follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain;Postoperative recovery quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, heart rate;Vasoactive drug use;Riker sedation-agitation score;Ramsay Sedation Score; | — |
Countries
China
Contacts
Public ContactWang Dalong
Shengli Oilfield Central Hospital, Dongying City, Shandong Province
Outcome results
None listed