Helicobacter pylori
Conditions
Interventions
Group 1:Tetracycline (500 mg bid) + vonoprazan (20 mg bid), 14 days
Group 2:Tetracycline (500 mg tid) + vonoprazan (20 mg bid), 10 days
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years; 2. Initial treatment of patients; 3. Positive Hp infection confirmed by breath test (13-C breath manufacturer limited to Hedaway or 75mg Huagan, expiratory value >6 judged to be positive, such as patients whose expiratory value is in the critical range are not enrolled); 4. Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of Hp eradication; 2. History of drug allergy to eradication protocols; 3. Have Zollinger-Ellison syndrome or hyperacidity or have a history of hyperacid; 4. Gastric cancer, acute upper gastrointestinal bleeding, more than 2 peptic ulcers or ulcer diameter greater than 0.5cm; 5. History of gastrectomy surgery; 6. Suffering from serious underlying diseases (heart, liver, kidneys, etc.), suffering from serious psychological or psychiatric diseases; 7. Those who have used acid inhibitors or antibiotics within one month before HP eradication therapy; 8. Pregnant or lactating women; 9. There are other factors that the investigator considers unsuitable for the inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| the incidence of adverse events; | — |
Countries
China
Contacts
Public ContactHu Yi
The First Affiliated Hospital of Nanchang University
Outcome results
None listed