cardiopathy
Conditions
Interventions
The Oliceridine Group:Configuration method of the analgesic pump: 27 mg of oliceridine, 5 mg of tropisetron and normal saline are mixed to make up to 108 mL (0.25 mg/mL). Parameters of the analgesic p
The Sufentanil Group:100 µg of sufentanil, 5 mg of tropisetron and normal saline are mixed to make up to 100 mL (1 µg/mL). Parameters of the analgesic pump: The initial loading dose is 5 mL (5 µg), th
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective simple coronary artery bypass graft (CABG) surgery under general anesthesia and cardiopulmonary bypass. 2.American Society of Anesthesiologists (ASA) physical status classification: Grade ? to ?. 3.Age ranging from 18 to 75 years old. 4.Body mass index (BMI) between 18 and 27 kg/m².
Exclusion criteria
Exclusion criteria: 1. Sleep apnea syndrome 2.Myocardial infarction within the most recent 28 days 3.Left ventricular ejection fraction less than 45% 4.Use of positive inotropic drugs or mechanical assist devices to assist circulation before surgery 5. Severe liver function abnormalities (bilirubin > 20 mmol/L, international normalized ratio (INR) > 2.0) 6.Chronic kidney disease at stage 4 or 5 (glomerular filtration rate < 30 mL/min/1.73 m²) 7.History of cerebrovascular accident 8.History of Chronic Obstructive Pulmonary Disease (COPD) 9.History of surgery on vital organs (liver, kidney, brain, lung and heart) 10.History of cancer 11.Chronic autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid-induced respiratory depression,OIRD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the curve; | — |
Countries
China
Contacts
Public ContactChen Linlin
Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen Hospital
Outcome results
None listed