Laryngopharyngeal reflux (LPR), Voice disorder
Conditions
Interventions
Voice Therapy Only Group:Voice Therapy
Combined Treatment Group:Proton Pump Inhibitor Combined with Voice Therapy
Sponsors
The First Affiliated Hospital,Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 60 years, no gender restriction. 2.Single positive RFS or RSI score (RFS > 7 and RSI = 13, or RFS = 7 and RSI > 13). 3.Complaints of voice disorders with symptoms persisting for at least 4 weeks, including hoarseness, difficulty in phonation, or changes in voice quality. 4.Willing to comply with treatment and follow-up, and able to complete questionnaire assessments and voice analysis as required. 5.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of other diseases that may cause voice disorders, such as vocal cord paralysis, laryngeal cancer, or laryngeal papilloma. 2.Acute respiratory infection or acute laryngitis within the past 4 weeks. 3.Diagnosed allergic diseases (e.g., allergic rhinitis, chronic sinusitis). 4.Treatment with PPI or other acid-suppressing medications within the past 6 months, or a known history of allergy to PPI. 5.Smoking or alcohol consumption more than 3 days per week. 6.Pregnant or lactating women. 7.Patients with mental disorders or those unable to cooperate with the study. 8.Inability to complete follow-up or a clear statement of intention to withdraw from the study. 9.Other diseases or special conditions that, in the investigator’s judgment, may affect the study results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective Rate of Voice Disorder Improvement;Reflux Symptom Index (RSI); | — |
Secondary
| Measure | Time frame |
|---|---|
| voice analysis(Jitter?Shimmer and MPT);Grade, Roughness, Breathiness, Asthenia, Strain Scale (GRBAS); | — |
Countries
China
Contacts
Public ContactDengjie
The First Affiliated Hospital,Sun Yat-sen University
Outcome results
None listed