Myocardial Ischemia-Reperfusion Injury
Conditions
Interventions
Patients with Acute Coronary Occlusion Undergoing Reperfusion:no
Individuals with Normal Hemodynamic Parameters on Coronary Angiography:no
Sponsors
The 960th hospital of the Joint Logistics Support Force of the People’s Liberation Army
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Experimental Group (Patients with Acute Coronary Occlusion Undergoing Reperfusion) 1. Meeting diagnostic criteria for acute coronary occlusion. 2. Emergency PCI confirmed at least one major coronary artery with complete occlusion (TIMI flow grade 0). 3. Successful reperfusion post-emergency PCI with restored TIMI flow grade 1–3 in the occluded vessel. 4. Patients or their legal guardians provided written informed consent for study participation. Control Group (Individuals with Normal Hemodynamic Parameters on Coronary Angiography) 1. Coronary angiography showing no significant stenosis (luminal stenosis <30%) and TIMI flow grade 3. 2. No history of myocardial infarction or other severe cardiovascular diseases. 3. Patients provided written informed consent for study participation.
Exclusion criteria
Exclusion criteria: Exclusion criteria included any of the following: 1. Severe cardiovascular diseases, hepatic or renal dysfunction, malignant tumors. 2. Hypersensitivity to the investigational drug or related medications, or recent use of drugs that may affect HPSE levels. 3. Recent percutaneous coronary intervention (PCI) or other cardiac surgeries. 4. Pregnancy or lactation, psychiatric or neurological disorders, or inability to cooperate and complete the study. Participants meeting any one of the above criteria were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heparanase; | — |
Secondary
| Measure | Time frame |
|---|---|
| N-terminal pro-B-type natriuretic peptide;Low-Density Lipoprotein; | — |
Countries
China
Contacts
Public ContactQun Jin
The 960th hospital of the Joint Logistics Support Force of the People’s Liberation Army
Outcome results
None listed