Skin diseases
Conditions
Interventions
Control group:Control solvent+high intensity training
Experiment group:Sodium Bicarbonate+high intensity training
Sponsors
Xiangtan First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Basic inclusion conditions Demographic indicators Age: 18~40 years old (including boundary value) Gender: unlimited (gender distribution needs to be recorded, and the final enrollment needs to meet the sex ratio of 1:1 between the experimental group and the control group) BMI index: 18.5= male, 120 g/L>= female White blood cell count: (4~10)×10?/L Fasting blood glucose: 3.9~6.1 mmol/L Four blood lipids: Total cholesterol =50th percentile value for age and sex No abnormal ST segment changes in exercise stress test (Bruce protocol assessment) Baseline test of physical fitness 1 minute push-up >= 20 times for men and 12 times for women Seated forward bend >= +10 cm (5) Other access requirements Legal and cognitive requirements Persons with full capacity for civil conduct who hold valid identity certificates; Pre-authorization informed consent process: Read the informed consent form completely and sign it independently> designated agent reads the informed consent form and signs it independently> designated agent reads and signs the informed consent form If there is a designated agent, the designated agent needs to sign the informed consent form together with the agent's relevant documents. Study Adherence: Commitment to continuous participation in the training program (attendance>=85%) Agree to comply with the dietary management of the study side (>= 20 hours per day)
Exclusion criteria
Exclusion criteria: If any of the following criteria is met, subjects cannot be enrolled in this interventional study: (1) Participated in any interventional clinical study (including drug and instrument biologics trials) within 3 months before enrollment; (2) History of major systemic diseases (need to meet the current clinical significance), the details are as follows: Circulatory system diseases (such as coronary heart disease, hypertension level II or above, severe arrhythmia), metabolic endocrine diseases (diabetes, hypothyroidism, etc.), urinary system diseases (chronic kidney disease stage 3 and above), neurological diseases (epilepsy, stroke sequelae, etc.), immune system abnormalities (primary acquired immune deficiency, autoimmune diseases), other system diseases (hematologic system, respiratory system, mental diseases, etc.); (3) Renal function limitation requirements (serum creatinine needs to be standardized detection methods) CockcroftGault formula calculates creatinine clearance (CrCl) <80mLémin; CrCl = [(140 age) × weight (kg)] / [0.814 × Scr(µmol/L)] (4) Clinical examination abnormalities, any of the following clinically significant abnormalities (researchers judged): abnormal signs of physical examination, pathological changes in ECG, laboratory test values ??exceeding the normal range by more than 20%, significant abnormalities in ultrasound radiation imaging, and continuous deviations from the baseline value; (5) Other situations that are not suitable for selection: After comprehensive evaluation by the research team, there are special circumstances that affect the integrity of the study or the safety of the subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin condition assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Blood biochemistry;Blood high-throughput sequencing;Serum inflammatory factor ;Magnetic resonance examination; | — |
Countries
China
Contacts
Public ContactGenqing Xie
The first people's hospital of Xiangtan hospital
Outcome results
None listed