Pancreatic cancer
Conditions
Interventions
Intervention group:"Double stent" placement of bile duct combined with pancreatic duct
Control group:"Single stent" placement of bile duct
Sponsors
Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University(( shanghai changhai hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Pancreatic cancer patients who are not candidates for surgical resection; 2.Presence of obstructive jaundice; 3.Pancreatic duct dilation confirmed by imaging examinations (e.g., ultrasound, CT, MRI, or endoscopic ultrasound); 4.Pancreatic cancer-related upper abdominal or back pain with a Numerical Rating Scale (NRS) score >=4; 5.No prior radiotherapy or chemotherapy before enrollment; 6.Age >=18 years.
Exclusion criteria
Exclusion criteria: 1.Patients with suspected concurrent malignancies in other sites; 2.Patients with altered gastrointestinal anatomy due to previous pancreatic or abdominal surgery; 3.Concurrent enrollment in other drug or therapeutic trials within 30 days prior to study initiation; 4.Expected survival <3 months; 5.Pain with a definitive non-cancer etiology (e.g., peptic ulcer disease, rheumatoid arthritis); 6.Contraindications to ERCP (e.g., uncorrectable coagulopathy, cardiopulmonary insufficiency); 7.Prior receipt of pain management interventions (e.g., celiac plexus neurolysis (CPN), intrathecal/epidural analgesia, or radioactive iodine seed implantation); 8.Patients with psychiatric disorders or inability to cooperate with pain/quality of life assessments; 9.Patients refusing study participation or declining informed consent; 10.Any other factors deemed by investigators to compromise study eligibility or participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective rate of pain relief; | — |
Secondary
| Measure | Time frame |
|---|---|
| Doses of opioid analgesics ;Mini Nutritional Assessment (MNA) score;Quality of Life Score (EORTC QLQ-C30);Incidence of post-ERCP adverse events;Effective duration of pain relief;Changes in liver function;Success rate of stent placement;Changes in amylase ; | — |
Countries
China
Contacts
Public ContactLei Wang
Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University(shanghai changhai hospital)
Outcome results
None listed