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Mechanism of immune escape induced by ITIM motifs of Helicobacter pylori CagA protein regulating host SHP1/TAK1/NF-?B pathway and its diagnostic value in gastric cancer

Mechanism of immune escape induced by ITIM motifs of Helicobacter pylori CagA protein regulating host SHP1/TAK1/NF-?B pathway and its diagnostic value in gastric cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500101234
Enrollment
Unknown
Registered
2025-04-22
Start date
2025-05-07
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stomach adenocarcinoma

Interventions

Chronic gastritis group:None
Gastric ulcer group:None
Duodenal ulcer group:None
Gastric cancer group:None

Sponsors

The Seventh Affiliated Hospital of Sun Yat-Sen University(Shenzhen)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Patients with chronic gastritis, gastric ulcers, duodenal ulcers, and gastric cancer positive for H. pylori infection; 2.Did not receive anti-H. pylori treatment or take antibiotics or hormonal medications for two months prior to the gastroscopy;

Exclusion criteria

Exclusion criteria: 1.None;

Design outcomes

Primary

MeasureTime frame
ITIM sequence quantity;ITIM gene polymorphism;—

Secondary

MeasureTime frame
CagA positive ratio;—

Countries

China

Contacts

Public ContactLuo Zhaofan

The Seventh Affiliated Hospital of Sun Yat-Sen University(Shenzhen)

luozhaofan@qq.com+86 18002295130

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026