traumatic brain injury
Conditions
Interventions
Gold Standard:GFAP is a key neurobiomarker for TBI diagnosis and prognosis, with elevated levels correlating closely with injury severity. CT imaging, combined with the Rotterdam score, is the gold st
Index test:Serum MFGE-8 levels will be measured using the ELISA (enzyme-linked immunosorbent assay) method.
Sponsors
Ganzhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign the informed consent form; 2. Age >= 18; 3. Admitted to the NICU within 12 hours post-injury and received standardized treatment protocols; 4. TBI diagnosis is confirmed, and the classification follows the TCDB standards; 5. A cranial CT scan is performed within 24 hours post-injury to confirm the presence of primary and secondary damage;
Exclusion criteria
Exclusion criteria: 1. A history of neurological diseases (stroke, epilepsy, Alzheimer's disease, Parkinson's disease); 2. Comorbid severe infections, immune system diseases, or malignant tumors that may affect MFGE-8 expression; 3. A history of previous cranial surgery or recent head trauma (within the past 6 months); 4. Severe multiple injuries (AIS =3) that affect TBI assessment; 5. Pregnant or breastfeeding women; 6.Individuals deemed by the investigator to be unsuitable for participation in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Outcome Scale(GOS);specificity;sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Death; | — |
Countries
China
Contacts
Public ContactZou Mingang
Ganzhou People's Hospital
Outcome results
None listed