Severe drug-resistant bacterial infections in children
Conditions
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. children with multidrug-resistant bacterial infection (based on the drug sensitivity test results of our hospital or other hospitals above grade 3a); 2. the pathogenic bacteria infected by the patient should meet one of the following conditions: (1) The pathogen was pandrug resistant bacteria (PDR); (2) The pathogen was carbapenem resistant organisms (CRO); (3) Pathogenic bacteria are sensitive to key antibiotics in vitro, but the antibiotic treatment is clinically ineffective or ineffective (ineffective effect is defined as the clinical efficacy is not obvious, the condition is not improved or worsened, and microbiological treatment is ineffective (pathogenic bacteria cannot be cleared)); (4) The use of key sensitive antibiotics by pathogenic bacteria is limited (such as organ toxicity or patients allergic to this antibiotic); 3. be able to screen at least one lytic phage (not required for virtual matching);
Exclusion criteria
Exclusion criteria: 1. there is no other route of administration except intravenous administration; 2. patients judged by the investigator to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Target bacterial clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical outcome; | — |
Countries
China
Contacts
Public ContactGangfeng Yan
Children's Hospital of Fudan University
Outcome results
None listed