non-alcoholic fatty liver disease
Conditions
Interventions
6-17 year old school children and adolescents :No
Sponsors
The Second Affiliated Hospital of Hainan Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 17 Years
Inclusion criteria
Inclusion criteria: Primary, junior high, and high school students aged 6–17 years, regardless of sex. Abdominal ultrasound findings meeting the diagnostic criteria for non-alcoholic fatty liver disease (NAFLD) as defined in the Guidelines for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (2018 Update). Ultrasound Diagnostic Criteria (must meet both of the following):Diffuse enhancement of near-field echogenicity in the liver, with echogenicity greater than that of the kidney. Blurred visualization of intrahepatic vessel structures. Progressive attenuation of far-field echogenicity.
Exclusion criteria
Exclusion criteria: 1 Merge other liver diseases (alcoholic fatty liver, viral fatty liver, autoimmune hepatitis, etc.) and drug-related fatty liver (corticosteroids, valproic acid, tamoxifen, methotrexate, amiodarone, etc.), as well as weight loss related fatty liver; 2 Individuals who have taken PPI, H2 receptor antagonists, bismuth supplements, antibiotics, synbiotics, probiotics, or other drugs that have altered their gut microbiota within one month; 3 Individuals who have undergone colonoscopy within one month, those with acute or chronic gastrointestinal inflammation, pregnant women, those with multiple underlying diseases that are difficult to study, and those with mental illnesses; Renal dysfunction and liver transplant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| abdominal ultrasonography;Fecal microbiota metagenome;Fecal microbiota ITS; | — |
Countries
China
Contacts
Public ContactFeiHu Bai
The Second Affiliated Hospital of Hainan Medical University
Outcome results
None listed