Colorectal cancer
Conditions
Interventions
SK Group:During surgery: 1.5% sevoflurane inhalation + propofol + esketamine 0.2mg/(kg·h), intermittent garrocuronium, 0.75% ropivacaine 5ml(if the operation time is more than four hours, then the sam
S Group:During surgery: 1.5% sevoflurane inhalation + propofol + normal saline ml/h pump, intermittent garrocuronium, 0.75% ropivacaine 5ml(if the operation time is more than four hours, then the same
Sponsors
Jintang County First People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged 60 to 85 years old, BMI(18.5-30kg/m2), laparoscopic assisted radical resection of colon cancer or rectal cancer; 2.Routine examination was basically normal (liver and kidney function, coagulation function, blood routine examination, electrocardiogram, chest CT),;3.ASA grade: I-II; Cardiac function: Grade 1-2.
Exclusion criteria
Exclusion criteria: 1.Mental patients. 2. Those with a history of using esketamine and allergies, or those with sedative drugs and drug dependence. 3.People with infectious diseases. 4.Patients who are participating in other clinical trials. 5.scoliosis deformity, unable to perform epidural puncture operation..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;Recovery time;Extubation time;Intraoperative propofol dosage;Sufentanil dosage;Dosage of ropivacaine;Pain visual analogue scale (VAS);Anal exhaust time;Length of stay;Total number of PCA compressions; | — |
Countries
China
Contacts
Public ContactQu Yang
Jintang County First People's Hospital
Outcome results
None listed