The influence of penehyclidine hydrochloride on postoperative pulmonary complications in patients undergoing laparoscopic radical gastrectomy for gastric cancer: A prospective, randomized, interventional study

The influence of penehyclidine hydrochloride on postoperative pulmonary complications in patients undergoing laparoscopic radical gastrectomy for gastric cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500101199

Enrollment

Unknown

Registered

2025-04-22

Start date

2025-05-10

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary complications after radical gastrectomy

Interventions

Experimental group (Group P):Intravenous injection of penehyclidine hydrochloride 0.5mg (diluted to 5ml with normal saline) before anesthesia induction

Control group (Group C):The same volume of normal saline was given intravenously

Eligibility

Sex/Gender

All

Age

60 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Age 60~70 years old; (2) Patients and their families are fully informed, agree to participate in this study, and sign an informed consent form for themselves and their families; (3) American Society of Anesthesiologists (ASA) grade II~III; (4) Laparoscopic radical gastrectomy under general anesthesia is planned to be elective.

Exclusion criteria

Exclusion criteria: (1) Patients with a history of moderate to severe prostatic hypertrophy or glaucoma; (2) Nebulized inhaled B2 receptor agonist, M-blocker or glucocorticoid within 1 month before surgery; (3) New stroke within three months; (4) Myocardial infarction, severe cardiac insufficiency or tachyarrhythmia within 1 year; (5) Severe renal dysfunction, severe liver dysfunction (Child-Pugh grade C); (6) Participate in other drug clinical studies within 1 month before surgery.

Design outcomes

Primary

Measure	Time frame
Incidence of pulmonary complications within 7 days (including 7 days) after surgery;	—

Secondary

Measure	Time frame
Intraoperative respiratory dynamics: airway driving pressure, mechanical power, peak airway pressure, positive end-expiratory pressure, dynamic lung compliance;Blood gas analysis: PaO2, PaCO2, Oxygenation index (OI), Respiratory index (RI), alveola-arterial blood oxygen differential pressure (A-aDO2);Incidence of postoperative delirium;Incidence of postoperative nausea and vomiting;Incidence of dry mouth, pharyngeal discomfort, rash and dilated pupils;	—

Measure

Time frame

Intraoperative respiratory dynamics: airway driving pressure, mechanical power, peak airway pressure, positive end-expiratory pressure, dynamic lung compliance;Blood gas analysis: PaO2, PaCO2, Oxygenation index (OI), Respiratory index (RI), alveola-arterial blood oxygen differential pressure (A-aDO2);Incidence of postoperative delirium;Incidence of postoperative nausea and vomiting;Incidence of dry mouth, pharyngeal discomfort, rash and dilated pupils;

—

Countries

China

Contacts

Public ContactGao Yubo

General Hospital of Ningxia Medical University

499700674@qq.com+86 135 9520 7076

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026