The effect of perioperative intravenous infusion of lidocaine on chronic post-surgical pain in patients undergoing total laparoscopic hysterectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500101183

Enrollment

Unknown

Registered

2025-04-21

Start date

2023-12-01

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic post-surgical pain in patients undergoing total laparoscopic hysterectomy

Interventions

LIDO group (lidocaine group):Inject 1.5mg/kg lidocaine intravenously before induction, and pump continuously at a rate of 2mg/(kg · h) during surgery until completion.

control group (normal saline group):The control group was infused with the same dose of normal saline in the same manner.

Eligibility

Sex/Gender

Female

Age

45 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. ASA I and II 2. Age range: >=45 and =18 and <=30 kg/m^2 4. Preoperative examination and testing showed no significant abnormalities

Exclusion criteria

Exclusion criteria: 1. Merge with severe heart, lung, liver, kidney, brain, endocrine or hematological diseases 2. Chronic arrhythmia with second or third degree atrioventricular block or baseline heart rate below 45 beats per minute 3. History of Anesthetic Drug Allergies 4. History of chronic pain 5. Long term use of analgesic drugs 6. Preoperative anxiety and depression symptoms or long-term use of psychotropic drugs 7. Severe audiovisual impairment preventing communication

Design outcomes

Primary

Measure	Time frame
Incidence and pain intensity of chronic post-surgical pain at 3 months;Differences in neutrophil-lymphocyte ratio (NLR) between preoperative and postoperative 48 hours;	—

Secondary

Measure	Time frame
Perioperative hemodynamic indicators;Intraoperative remifentanil consumption;Average NRS scores for resting and active states 24 hours after surgery;Incidence of throat pain 24 hours after surgery;Recovery rate of pain relief in the ward 48 hours after surgery;Postoperative nausea and vomiting incidence rate;First anal exhaust time after surgery;PACU dwell time;Duration of hospitalization;Incidence of perioperative adverse events;The relationship between the incidence of chronic post-surgical pain at 3 months and acute pain intensity;	—

Measure

Time frame

Perioperative hemodynamic indicators;Intraoperative remifentanil consumption;Average NRS scores for resting and active states 24 hours after surgery;Incidence of throat pain 24 hours after surgery;Recovery rate of pain relief in the ward 48 hours after surgery;Postoperative nausea and vomiting incidence rate;First anal exhaust time after surgery;PACU dwell time;Duration of hospitalization;Incidence of perioperative adverse events;The relationship between the incidence of chronic post-surgical pain at 3 months and acute pain intensity;

—

Countries

China

Contacts

Public ContactPeiwen Jia

Benxi Central Hospital

912926097@qq.com+86 133 0814 5881

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026