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Analgesic effect of bupivacaine liposomes used for ultrasound-guided transverse abdominal muscle plane block after laparoscopic radical resection of colorectal cancer

Analgesic effect of bupivacaine liposomes used for ultrasound-guided transverse abdominal muscle plane block after laparoscopic radical resection of colorectal cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101176
Enrollment
Unknown
Registered
2025-04-21
Start date
2025-04-21
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative analgesia

Interventions

Experimental group:On each side, bupivacaine liposome 10ml+0.9% normal saline 10ml was used for posterior ultrasound-guided abtral transversal plane block
Control group:0.25% bupivacaine injection 20ml on each side was used for posterior ultrasound-guided abdominalis transversal plane block

Sponsors

Mianyang Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Voluntarily sign the informed consent form to fully understand the purpose and significance of this trial; Patients undergoing laparoscopic radical resection of nodal/rectal cancer under elective general anesthesia; 40 years old< = age< = 75 years, gender is not limited; 18kg/m^2<=body mass index (BMI) <=28kg/m^2 ; 2cm<=surgical incision<=10cm, blood loss<=800ml; American Society of Anesthesiologists (ASA) Class II.~III.

Exclusion criteria

Exclusion criteria: Allergic to local anesthetics; Inability to correctly understand VAS/NRS scores and PCIA pump use; Complicated with severe cardiopulmonary dysfunction or abnormal liver and kidney function; The puncture site was infected and the ultrasonography showed unclear anatomical structure. Patients with severe abnormal coagulation function; Colorectal tumor TNM stage III or IV; History of chronic pain; He was transferred to open surgery for special reasons.

Design outcomes

Primary

MeasureTime frame
Pain score;

Secondary

MeasureTime frame
Total number of analgesic pump compressions;Number of effective compressions of the analgesic pump;Opioid consumption;Remedial analgesics and dosage;Incidence of postoperative nausea and vomiting;Anal exhaust time;First time out of bed activity;Postoperative analgesia satisfaction score;Incidence of adverse reactions;

Countries

China

Contacts

Public ContactLi Juan

Mianyang Central Hospital

493105515@qq.com+86 136 1811 8180

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026