Resistant hypertension
Conditions
Interventions
b) Low-renin hypertension: prefer increasing the dose of diuretics, using calcium channel blockers, and emphasizing a low-salt diet
c) Normal-renin hypertension: prefer calcium channel blockers, a-blockers, and diuretics.
Control Group:None
Hormone Level Measurement Group :At baseline and follow-up, patients should also undergo blood tests for standing plasma renin, angiotensin II, and aldosterone every six months. Adjust the types and
Precise Sodium Salt Restriction Group:Strengthen patient education on salt restriction, encouraging patients to strictly control sodium intake in their daily diet. Measure 24-hour urinary sodium and p
Precise Sodium Salt Restriction+Hormone Level Measurement Group :Strengthen patient education on salt restriction, encouraging patients to strictly control sodium intake in their daily diet. Measure
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with hypertension aged 18-70 years, regardless of gender. 2. Blood pressure above target despite being on 3 or more different types of antihypertensive medications (including a diuretic). 3. Sign a consent form.
Exclusion criteria
Exclusion criteria: 1. Severe organ (heart, liver, kidney) dysfunction 2. Poor treatment compliance 3. Currently participating in other clinical research projects 4. Women preparing for pregnancy and during pregnancy 5. Unable to cooperate to complete the relevant laboratory tests required by the study 6. Diagnosis of secondary hypertension 7. Hospitalized in the past 6 months due to acute cardiovascular events 8. Planned surgical procedures or coronary revascularization within the next year 9. Malignant tumors, dementia, or severe mental disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure target achievement rate ;Proportion of subclinical target organ damage progression assessed through urine albumin-to-creatinine ratio, serum creatinine, left ventricular mass index, and fundus.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in systolic blood pressure;Change in diastolic blood pressure;A composite endpoint consisting of cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure, hospitalization for other cardiovascular reasons, and recommendation for renal denervation treatment; | — |
Countries
China
Contacts
Public ContactXiaowei Yan
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed