Non-alcoholic fatty liver disease
Conditions
Interventions
Non-alcoholic fatty liver group:None
Control group:None
Sponsors
Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hepatic steatosis (ultrasound and/or magnetic resonance imaging) and/or histological analysis of liver biopsy on liver imaging: fat content >=5%; 2. Daily alcohol consumption less than 10g for women and less than 20g for men; 3. No lipogenic drugs (glucocorticoids, methotrexate, amiodarone, tamoxifen, etc.); 4. No other chronic liver diseases, such as viral hepatitis, autoimmune hepatitis, toxic liver injury, alcoholic steatohepatitis, cholestatic liver disease, Wilson's disease and hereditary hemochromatosis.
Exclusion criteria
Exclusion criteria: 1. Oral or intravenous antibiotics within 6 months prior to the study, pregnancy; 2. Age < 18 years old; 3. Presence of acute inflammation; 4 Further Exclusion Criteria: (1) Participation in an interventional nonalcoholic steatohepatitis (NASH) study within three months prior to enrollment or currently or before; (2) Successful lifestyle change, weight loss of more than 5%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of miR-106b-5p; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oil Red O staining positive area;Non-alcoholic fatty liver disease Activity Score;Alanine transaminase;Aspartate aminotransferase;Triglyceride;Very Low Density Lipoprotein,VLDL; | — |
Countries
China
Contacts
Public ContactXiangming Fang
Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Outcome results
None listed