Depression
Conditions
Interventions
control group:sham intermittent theta burst stimulation (iTBS) treatment
Experimental Group:Intermittent theta burst stimulation (iTBS) treatment
Sponsors
Zhong Shan Third Peoples' Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for depressive episode (F32.1, F32.2) in the International Classification of Diseases, 10th Revision (ICD-10); 2. Be between 14 and 18 years old, regardless of gender; 3.Be in the acute phase of a depressive episode; 4. Have a HAMD-24 score of >=20, and a score on item 4 or 5 of the Beck Scale for Suicide Ideation (BSI) of >0; 5. Have received at least primary school education or above; 6. Understand the purpose and content of the study, and be willing to cooperate in completing it; 7. The patient and guardian have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a history of diseases affecting the central nervous system or severe physical illnesses; 2.Have a risk of epileptic seizures or a family history of epilepsy, such as abnormal electroencephalograms (EEGs) or abnormal brain magnetic resonance imaging (MRI) results; 3. Have a history of abuse or dependence on psychoactive substances; 4. Have absolute contraindications for rTMS, that is, metallic implants in the cranial cavity; 5. Have received rTMS, electroconvulsive therapy, or other electrical or magnetic stimulation treatments within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-item Hamilton Depression Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Beck Scale for Suicide Ideation;Ottawa Self-Injury Inventory;Stroop Word-Color Interference test;Wisconsin card sorting test;Event-related potentials P300;Record of adverse reactions to TMS treatment; | — |
Countries
China
Contacts
Public ContactZhang jie
Zhong Shan Third Peoples' Hospital
Outcome results
None listed