Valvular heart disease
Conditions
Interventions
Blank control group (Group C):no-intervention
Furosemide atomization Group (M group):At the beginning of the operation, the nebulizer, anesthesia circuit and ultrasonic atomizer were connected through T-shaped tube and atomized inhalation was per
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. ASA grade III~IV; 3. Cardiac function grade I to III; 4. Ethical, sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient is currently taking immunosuppressant drugs or complicated with diabetes, chronic respiratory diseases, severe liver and kidney dysfunction, immune diseases, and blood diseases; 2. in the active infection stage (leukocyte 10 x 10^9/L); 3. Preoperative ultrasound indicated severe pulmonary hypertension or left ventricular dysfunction: left ventricular ejection fraction (LVEF) 70 mm, cardiothoracic ratio > 0.7; 4. BMI > 35 kg/m^2; 5. Preoperative poor pulmonary oxygenation, blood oxygen saturation < 90%, blood oxygen saturation < 95% when inhaling pure oxygen; 6. People with known allergies to furosemide
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lowest murray lung injury score within 6 hours after surgery;Incidence of lung injury 6h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Internal environmental parameters include arterial blood gas, crystal osmotic pressure, CVP and lactic acid;Respiratory parameters included peak airway pressure, PEEP and dynamic lung compliance;Cell counts in bronchoalveolar lavage fluid(BALF);NO content in BALF;TNF-a content in BALF;Interleukin-6 content in BALF;Interleukin-1ß content in BALF;Intercellular adhesion molecule-1 (ICAM1) content in BALF;Angiopoietin-2 content in BALF;Content of alveolar surface active protein D (SP-D) in BALF;TNF-a content in venous blood;NO content in venous blood;IL-6 content in venous blood;IL-1ß content in venous blood;ICAM1 content in venous blood;Content of pulmonary alveolar surface active protein-D in venous blood;Vascular blood angiopoietin-2 content;Time of postoperative ventilator assistance;ICU stay;Postoperative recovery time (postoperative to discharge time);hospital stays;Secondary intubation rate;Demand for non-invasive ventilation in general wards after surgery;Serious adverse events after surgery;Oxygenation index;Chest radiograph;echocardiography;C-reactive protein;Systemic inflammatory index;Neutrophil/lymphocyte ratio;Platelet/lymphocyte ratio;Urea nitrogen/serum protein ratio; | — |
Countries
China
Contacts
Public ContactQi Mao
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed