Acinetobacter baumannii infects the lower respiratory tract
Conditions
Interventions
Gold Standard:1. Clinical Presentation. Symptoms: Fever, cough, sputum (possibly purulent), shortness of breath, chest pain, etc. Signs: On lung auscultation, there may be crackles, decreased breath s
Index test:1. BALF was collected from patients, and 10 µl of BALF specimens were taken and spotted on blood agar plates and chocolate agar plates respectively, with dense streaks, and cultured in a co
positive colonies were identified using Maldi-TOF.
2. Collect the bacteria and extract the whole genome, then design primers based on the selected target genes (e.g., GTR100) to perform PCR testing fo
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged 18 years or older who meet the diagnostic criteria for Acinetobacter baumannii pneumonia in the 2012 "Expert Consensus on Diagnosis, Treatment and Prevention of Acinetobacter baumannii Infection in China": (1) General manifestations of bacterial infection (such as fever, increased white blood cells and/or neutrophils, and C-reactive protein); (2) New, persistent, or worsening pulmonary exudates, infiltrations, and consolidations on clinical symptoms and signs consistent with pneumonia and imaging; (3) Presence of susceptible host factors, including underlying diseases, immune status, prior use of antibiotics, and other risk factors associated with the onset of the disease such as mechanical ventilation time; (4) Patients who are receiving antibiotics improve for a time and then worsen again, which is consistent with the appearance of Acinetobacter baumannii in time; (5) More than two sputum cultures show pure growth of Acinetobacter baumannii or dominant growth of Acinetobacter baumannii, and the evaluation of specimen collection methods, specimen quality, bacterial concentration (quantitative or semi-quantitative culture), smear findings, etc. are clinically significant.
Exclusion criteria
Exclusion criteria: 1) Patients with concurrent infections in other parts of the body, such as bloodstream infection, abdominal infection, urinary tract infection, skin and soft tissue infection, intracranial infection, etc.; 2) Patients with concurrent infections with other pathogens besides Acinetobacter baumannii; 3) Asymptomatic infected or colonized patients without abnormal auxiliary examination results and treatment with antimicrobial drugs; 4) Pregnant or lactating women; 5) Patients with a recent history of surgery or major trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| routine analysis of blood;SOFA scoring;APACHE-II scoring;hepatic and renal function;Cell morphological examination of BALF ;blood gas analysis;coagulation function; | — |
Secondary
| Measure | Time frame |
|---|---|
| GCS scoring;Myocardial enzymology; | — |
Countries
China
Contacts
Public ContactFei Shi
Shenzhen People's Hospital
Outcome results
None listed