Membranous Nephropathy
Conditions
Interventions
Sponsors
Wuxi People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18-80 years (including both 18 and 80), gender, and ethnicity are not restricted. 2.Patients diagnosed with primary membranous nephropathy (PMN) according to the KDIGO 2021 diagnostic criteria, regardless of whether they have received immunosuppressive treatment. 3.Individuals with the capacity for autonomous decision-making who can independently decide whether to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Onset of nephrotic syndrome in infants and children. 2.Secondary membranous nephropathy (e.g., associated with systemic autoimmune diseases, solid or hematologic malignancies, chronic hepatitis B virus infection, and other infections) or prolonged use of certain medications (e.g., gold salts, nonsteroidal anti-inflammatory drugs [NSAIDs], penicillamine). 3.History of malignant tumors. 4.Currently undergoing kidney dialysis or expected to require dialysis during the study. 5.Abnormal liver function, with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels exceeding three times the upper limit of normal. 6.Inability to cooperate with researchers in basic information collection due to various reasons (e.g., hearing impairment, language barriers). 7.Other reasons that the researcher deems unsuitable for participation in the study (e.g., low willingness to cooperate, difficulties in long-term follow-up).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urine protein quantification;Anti-phospholipase A2 receptor antibody IgG;Anti-phospholipase A2 receptor antibody domain- IgG/IgG4 antibodies;Serum creatinine;Serum Albumin;Urine Protein-to-Creatinine Ratio ;Urine Protein;Estimated glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anti-Phospholipase A2 Receptor Antibody Gene Polymorphism;Alanine Aminotransferase;Aspartate Aminotransferase;Fasting Blood Glucose;Serum Potassium;Total Cholesterol;Triglycerides;Cluster of Differentiation 20 Count;Tacrolimus concentration;Hemoglobin;Platelet count;Microscopic hematuria;Human Leukocyte Antigen gene polymorphism; | — |
Countries
China
Contacts
Public ContactWang Liang
Wuxi People's Hospital
Outcome results
None listed