postoperative delirium
Conditions
Interventions
Intravenous group:Nasal spray of normal saline was used before operation, and dexmedetomidine was pumped during operation
Nasal spray group:Dexmedetomidine was nasal sprayed before operation, and normal saline was pumped during operation
Control group:Normal saline was nasal sprayed before operation and pumped during operation
Sponsors
Hebei General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients aged >=65 years; 2. Elderly patients undergoing elective hip replacement or knee replacement under combined spinal-epidural block; 3. The expected length of hospital stay should be at least 3 days; 4. The American Society of Anesthesiologists (ASA) score was grade II-III;
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative cognitive impairment or previous history of cognitive impairment, dementia, and delirium; 2. Patients with preoperative sick sinus syndrome, severe bradycardia (heart rate <50 beats/min) or atrioventricular block of second degree or above, permanent pacemaker implantation, severe heart failure or ejection fraction <30%; 3. Patients with rhinitis who are not suitable to use nasal spray; 4. Allergic to dexmedetomidine nasal spray or other anesthetic drugs used in this study; 5. Patients who withdraw or die due to uncooperative or unexpected circumstances;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the severity of delirium;postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of sedation;Severity of cognitive impairment;Quality of Recovery Questionnaire (QoR-15 score);Level of anxiety; | — |
Countries
China
Contacts
Public ContactLi Jianli
Hebei General Hospital
Outcome results
None listed