Low Rectal and Colorectal Cancer
Conditions
Interventions
Non-stoma group:no
Stoma group:no
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Study participants aged 18-80 years; 2. Patients newly diagnosed with low rectal or colorectal cancer, scheduled to undergo stage I radical colorectal cancer surgery (Dixon procedure) along with prophylactic ileostomy, followed by ileostomy closure after six months, or stage I radical colorectal cancer surgery (Dixon procedure) alone; 3. Patients who have not received chemotherapy, radiotherapy, or immunotherapy prior to their colorectal cancer diagnosis; 4. Patients without significant dietary preferences (e.g., strong preferences for specific foods such as a pronounced liking for sweets or spicy foods); 5. No history of other gastrointestinal diseases (excluding intestinal polyps and gallstones); 6. Willing to participate in the study and sign informed consent; 7. For patients in the stoma group, the intraoperative confirmed length of the bypassed ileal segment is 15-20 cm.
Exclusion criteria
Exclusion criteria: 1. The patient was found to have multiple tumors during preoperative examinations; 2. The patient has concurrent infectious diseases or autoimmune diseases; 3. The patient has congenital or acquired metabolic disorders; 4. The patient took antibiotics or probiotics within two weeks prior to enrollment in the study; 5. The surgical plan was altered, and ileostomy was not performed during the first-stage surgery; 6. For certain reasons, the patient did not undergo stoma reversal; 7. Tumor progression occurred in the patient prior to the reversal surgery; 8. Life expectancy is less than one year; 9. End-stage tumor; 10. Complications such as cerebrovascular disease, neurodegenerative diseases, epilepsy, psychiatric disorders, brain tumors, anorexia, pica, uncontrolled obesity, or other conditions affecting food intake; 11. Special dietary practices such as vegetarianism or halal diets; 12. Presence of metallic implants in the body or claustrophobia, making the patient unsuitable for brain MRI; 13. A confirmed preoperative diagnosis of anxiety or depression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pallidal volume at T2 time point between the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Volumes of the globus pallidus and hypothalamus across different time points for each group;Psychological and behavioral questionnaires for each group at different time points;Gut and Serum Metabolomic Changes;Changes in Serum Hormone Levels;Colony changes in microbiome metagenomic analysis.;Characteristics of the globus pallidus and hypothalamic regions in 7T magnetic resonance spectroscopic imaging across different time points; | — |
Countries
China
Contacts
Public ContactYin Changlin
The First Affiliated Hospital of Army Medical University
Outcome results
None listed