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Impact of Liposomal Bupivacaine on Postoperative Pain in Elderly Patients Undergoing Total Knee Arthroplasty

Impact of Liposomal Bupivacaine on Postoperative Pain in Elderly Patients Undergoing Total Knee Arthroplasty

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101110
Enrollment
Unknown
Registered
2025-04-21
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Liposomal Bupivacaine Single-shot Adductor Canal Block Group:Liposomal Bupivacaine Adductor Canal Block: Ultrasound-guided localization of the mid-adductor canal: Place the ultrasound probe at the mid
Ropivacaine Single-shot Adductor Canal Block Group:Ropivacaine Adductor Canal Block Group: Ultrasound-guided localization of the mid-adductor canal: Place the ultrasound probe at the mid-femoral level
Continuous Ropivacaine Adductor Canal Block Group:Ultrasound-guided localization of the mid-adductor canal: Place the ultrasound probe at t

Sponsors

Pukou District Hospital of Traditional Chinese Medicine, Nanjing
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: Aged 60 to 85 years. American Society of Anesthesiologists (ASA) physical status classification I-III.Undergoing primary total knee arthroplasty (TKA) for the first time.Receiving single-shot adductor canal block (ACB) for postoperative analgesia.No contraindications to postoperative rehabilitation training.

Exclusion criteria

Exclusion criteria: Patients with a known allergy to liposomal bupivacaine or ropivacaine. Patients requiring postoperative intensive care unit (ICU) monitoring and treatment. Patients who refuse postoperative rehabilitation training. Patients with a history of long-term opioid use. Patients currently participating in other drug or clinical trials.

Design outcomes

Primary

MeasureTime frame
Postoperative Pain;

Secondary

MeasureTime frame
Postoperative Analgesic Usage;Knee Injury and Osteoarthritis Outcome Score (KOOS);Adverse Events Related to Peripheral Nerve Block;

Countries

China

Contacts

Public ContactDalei Zhou

Pukou District Hospital of Traditional Chinese Medicine, Nanjing

zhoudaleis@126.com+86 135 8519 2046

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026