Hand-foot syndrome/Hand-foot skin reaction
Conditions
Interventions
Intervention group:Hands and feet: treat with CICAPLAST BAUME B5 twice a day
Control group:Treat with Urea Ointment twice a day
Sponsors
Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) 18-85 years old, ECOG 0-2 score, cancer patients undergoing treatment. 2) Hand-foot reaction/hand-foot syndrome after tumor treatment include cytotoxic chemotherapy and molecular targeted drugs. 3) Patients voluntarily participate in clinical observation and sign informed consent, willing to cooperate with follow-up observation, with good communication skills and understanding skills 4) CTCAE grading greater than or equal to 2 points 5) Initial itching or pain VAS>3 points 6) During follow-up throughout the study, participants stopped using their usual emollients.
Exclusion criteria
Exclusion criteria: 1) Severe skin infection; 2) Allergic to the ingredients of the repair agent used in the study; 3) Serious heart, brain, lung, liver, kidney damage 4) Pregnant and lactating women 5) History of mental and psychiatric disorders and a recent history of alcohol or drug abuse 6) Being treated with radiation 7) Subjects may not be able to complete the study for other reasons or may not be considered appropriate by the investigator to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CTCAE grading improvement rate of Hand-Foot Syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS (pain);Transdermal water loss(TEWL);Skin hydration (Corneometer);VAS;Tumor Treatment Dose Maintenance Rate;Variation in Treatment Response Time;HF-QOL;Social Stigmatization PUDH-D questionnaire; | — |
Countries
China
Contacts
Public ContactMeng Pan/Hua Cao
Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University
Outcome results
None listed