Constipation
Conditions
Interventions
Sponsors
The Second People's Hospital of Jingdezhen
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: > = 45 years old who meet the criteria for chronic constipation in middle-aged and elderly people, with normal weight and height. Diagnostic criteria for chronic constipation in middle-aged and elderly people: 1. The following > = 2 items must be included. (1) At least 25% of the time, bowel movements are laborious; (2) At least 25% of the time the bowel movements are lumpy or hard; (3) at least 25% of the time, there is a feeling of incomplete bowel movements; (4) At least 25% of the time, there is anorectal obstruction or blockage; (5) At least 25% of the time defecation requires manual assistance (such as finger defecation assistance, pelvic floor support); (6) Spontaneous bowel movements less than 3 times a week. 2. Loose stools rarely occur when laxatives are not used. 3. Symptoms that do not meet the diagnostic criteria for irritable bowel syndrome with constipation (IBS-C) have appeared for at least 6 months before diagnosis, and the symptoms meet the above diagnostic criteria in the past 3 months.
Exclusion criteria
Exclusion criteria: 1. Subjects with previous or current intestinal obstruction, tumors, ulcers, and other diseases that may lead to secondary constipation of the digestive tract. 2. Subjects with a prior history of gastrointestinal surgery. 3. Subjects with major diseases, such as severe cardiovascular, liver, and kidney diseases. 4. Subjects who are allergic to probiotics. 5. Subjects who have taken antibiotics, probiotics, and other drugs that affect the efficacy evaluation within three weeks before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-HT;Composition of gut microbiota; | — |
Countries
China
Contacts
Public ContactJiangqing Yu
Jingdezhen Second People's Hospital
Outcome results
None listed