Polycystic Ovary Syndrome
Conditions
Interventions
The metformin group:Start oral letrozole on the 3rd day of menstruation, 2.5 mg/day, continuously for 5 days. Instruct the patient to undergo dynamic monitoring of follicle development by ultrasound o
if =15mm, monitor daily until the follicle diameter is =18mm, defined as mature follicle. Administer 10,000 units of human chorionic gonadotropin (HCG) intramuscularly to induce follicle rupture post-
Acupuncture group:Start taking oral letrozole on the 3rd day of menstruation, 2.5 mg/day, for 5 consecutive days. Instruct the patient to undergo dynamic monitoring of follicle development by transvag
if =15mm, monitor daily until the follicle diameter is =18mm, defined as a mature follicle. Administer 10000 units of human chorionic gonadotropin (HCG) by intramuscular injection to induce follicle r
Sponsors
Fujian Maternal and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Patients who meet the diagnostic criteria of Chinese and Western medicine; 2.Patients between the ages of 20 and 40 who have fertility requirements; 3.Patients with insulin resistance; 4.Those who voluntarily join and can perform regular visits.
Exclusion criteria
Exclusion criteria: 1.Patients with blood diseases, or with primary diseases such as liver, kidney, cardiovascular and cerebrovascular diseases, or mental diseases; 2.Exclude organic diseases or other endocrine disorders and other related diseases; 3. Patients who have taken hormone drugs such as ovulation stimulating drugs, glucocorticoids, contraceptives in the past 3 months, or have participated in other similar clinical trials; 4.Unable to complete the acupuncture treatment course, quit midway or lost visitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six sex hormones;Anti-Müllerian Hormone;Blood Sugar;Oral glucose tolerance test;Insulin Release Test;Interleukin-6;Record pregnancy status.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cholesterol;Triglyceride;Low-density lipoprotein-C;Lipoprotein(a);High-density lipoprotein-C;Reactive Oxygen Species;Malondialdehyde;Nitric oxide;Total Antioxidant Status;Superoxide Dismutase;Glutathione peroxidase;Interleukin-2;Interleukin-10;Tumor Necrosis Factor-a;Traditional Chinese Medicine Symptom Score;Ovarian follicle development;Endometrial thickness on ovulation day;Blood flow in the uterine cavity; | — |
Countries
China
Contacts
Public ContactYang Juan
Fujian Maternal and Child Health Care Hospital
Outcome results
None listed