Epilepsy
Conditions
Interventions
Observation group:None
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
8 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Patients with drug-resistant epilepsy requiring the implantation of deep brain electrodes for treatment; 2) Wechsler Intelligence Scale, full score and memory score both >60; 3) Patients with normal communication skills; 4) 12-60 years old.
Exclusion criteria
Exclusion criteria: 1) Patients with obvious malformations or abnormalities in the brain; 2) Patients with preivious history of craniotomy or intracranial electrode implantation; 3) Strong adverse reactions to functional electrical stimulation, such as palpitations, fear, and epileptic seizures; 4) Presence of other comorbidities, already having or requiring the implantation of cardiac pacemakers, defibrillators, and cochlear implants, etc.; 5) Serious heart, liver, kidney physical diseases or severe or progressive neurological and psychiatric diseases with severe arrhythmia, QTc>450ms; transaminase exceeding the upper limit of normal values (0-40U/L) by three times, total bilirubin (3.4-17.1 µ mol/L), creatinine (44-133umol/L) exceeding the upper limit of normal values by 1.5 times, or creatinine clearance rate<45ml/min.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalographic changes;Arithmetic behavioral changes; | — |
Countries
China
Contacts
Public ContactZhang Chunqing
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed