Clinical Presentation of Primary Central Nervous System Lymphoma (PCNSL): The clinical symptoms of PCNSL depend on the tumor's location within the central nervous system. Common manifestations include ?headache, ?seizures, ?focal neurological deficits, ?personality or cognitive alterations, and ?signs of elevated intracranial pressure (e.g., papilledema, nausea/vomiting). Approximately ?10%–20% o
Conditions
Interventions
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Prospective cohort study part: Age >= 18 years, regardless of gender; diagnosed with primary central nervous system lymphoma (PCNSL) according to EANO guidelines, with lesions limited to the central nervous system (brain, spinal cord, eyes, or leptomeninges), without evidence of systemic lymphoma; clinical plan to perform surgical biopsy or stereotactic biopsy to obtain clear histopathological diagnosis; the subject or their legal representative has fully understood the research content and voluntarily signed the informed consent form; patients who sought medical care at Southern Hospital of Southern Medical University between January 2025 and December 2030. 2.Retrospective cohort study part (requiring informed consent): Age >= 18 years, regardless of gender; diagnosed with primary central nervous system lymphoma (PCNSL) according to EANO guidelines, with lesions limited to the central nervous system (brain, spinal cord, eyes, or leptomeninges), without evidence of systemic lymphoma; clinical surgical biopsy or stereotactic biopsy has been performed to obtain clear histopathological diagnosis; the subject or their legal representative has fully understood the research content and voluntarily signed the informed consent form; patients who sought medical care at Southern Hospital of Southern Medical University between January 2024 and December 2024. 3.Retrospective cohort study part (proposing waiver of informed consent): Age >= 18 years, regardless of gender; diagnosed with primary central nervous system lymphoma (PCNSL) according to EANO guidelines, with lesions limited to the central nervous system (brain, spinal cord, eyes, or leptomeninges), without evidence of systemic lymphoma; clinical surgical biopsy or stereotactic biopsy has been performed to obtain clear histopathological diagnosis; not feasible to re-contact patients; patients who sought medical care at Southern Hospital of Southern Medical University between January 2000 and December 2023.
Exclusion criteria
Exclusion criteria: 1.Secondary Central Nervous System Lymphoma: Patients diagnosed with systemic lymphoma with central nervous system metastasis; 2.Other Central Nervous System Malignancies: Non-lymphocytic tumors such as gliomas, meningiomas, and other tumors not of lymphocytic origin; 3.Severe Organ Dysfunction: Such as severe cardiovascular disease, hepatic insufficiency, renal insufficiency, or other diseases that may affect survival prognosis; 4.Concurrent Severe Infection or Other Acute Diseases: Diseases that affect patient participation in the study or study results; 5.Pregnant or Lactating Women; 6.Patients deemed unsuitable for participation in this study based on the investigator's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate, ORR;Progression-Free Survival, PFS;Overall Survival, OS; | — |
Countries
China
Contacts
Public ContactHao Long
Southern Medical University Southern Hospital
Outcome results
None listed