Autism spectrum disorder
Conditions
Interventions
Transcranial Magnetic Stimulation (TMS) Group:Transcranial magnetic stimulation (TMS) intervention
Normal Control Group:None
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Aged 6–18 year; 2.Meets the diagnostic criteria for autism spectrum disorder (ASD) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 3.Normal liver and kidney function; 4.No concurrent acute or chronic organic diseases; 5.Voluntary participation with informed consent signed by both the participant (if capable) and their legal guardian.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for FMT Group: 1.Use of antibiotics within the past month or presence of active infection; 2.Organic diseases of the heart, lungs, liver, kidneys, or other major organs; 3.Comorbid psychiatric or neurological disorders (e.g., bipolar disorder, obsessive-compulsive disorder, epilepsy); 4.History of abdominal surgery; 5.Metabolic, endocrine, or autoimmune system disorders; 6.Genetic or chromosomal disorders; 7.Current participation in another interventional clinical trial; 8.Any other condition deemed unsuitable for enrollment by the investigators. Exclusion Criteria for TMS Group: 1.Severe organic brain diseases (e.g., epilepsy, stroke, encephalitis, traumatic brain injury) or severe systemic diseases (e.g., malignant tumors, acute heart failure, multi-organ failure); 2.Presence of metal implants above the chest, particularly in the brain or heart (contraindications for magnetic stimulation); 3.History of electroconvulsive therapy (ECT) within the past 6 months; 4.Substance or alcohol abuse within the last year; 5.Severe communication impairments affecting comprehension, compliance with instructions, or ability to cooperate with treatment and assessments; 6.Current participation in other drug or physical therapies (e.g., deep brain stimulation (DBS), ECT, or repetitive transcranial magnetic stimulation (rTMS)); 7.Any other condition considered unsuitable by the physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Social Responsiveness Scale;Autism Behavior Checklist;Autism Diagnostic Observation Schedule; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota analysis;Magnetic Resonance Imaging ;Electroencephalography;Eye-tracking; | — |
Countries
China
Contacts
Public ContactZhang Bin
Tianjin Anding Hospital
Outcome results
None listed