Spinocerebellar Ataxia
Conditions
Interventions
Healthy control group:NA
Test group:repeated transcranial magnetic stimulation
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Spinocerebellar ataxia patients confirmed through genetic testing; 2. Patient aged 18-75; 3. Patients who can walk independently (with the aid of a cane/walker) without assistance from others. 4. The SARA score exceeds 3.
Exclusion criteria
Exclusion criteria: 1. Patients with unstable neurological disorders or accompanying medical conditions (such as stroke, arthritis, etc.); 2. Patients with significantly abnormal clinical indicators identified during screening; 3. Patients concurrently participating in another clinical study; 4. Patients with untreated intracranial hypertension, depression, dementia, or psychiatric disorders; 5. Patients with severe heart disease; 6. Patients who are wheelchair users; 7. pregnant woman; 8. Patients who cannot establish their identity or have limited legal capacity; 9. Patients with contraindications for rTMS, including metallic objects in the head, history of neurosurgery, ferromagnetic bioimplants, metal coatings, history of seizures, autism, current use of protease inhibitors or other medications that may increase the risk of rTMS-induced seizures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale for the assessment and rating of ataxia (SARA);Resting - state electroencephalogram; | — |
Secondary
| Measure | Time frame |
|---|---|
| The International Cooperative Ataxia Rating Scale (ICARS);The Neurological Examination Score for the assessment of Spinocerebellar Ataxias (NESSCA);EuroQol five dimensions questionnaire;Gait analysis;Transcranial Magnetic Stimulation - Electroencephalogram(TMS-EEG); | — |
Countries
China
Contacts
Public ContactFei Xiao
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed