schizophrenia
Conditions
Interventions
Active Group:Active iTBS targeted at the dorsolateral prefrontal cortex
Sham Group:Sham iTBS targeted at the dorsolateral prefrontal cortex
Efficacy validation group:Active iTBS targeted at the dorsolateral prefrontal cortex
Sponsors
The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed using the Mini-International Neuropsychiatric Interview (MINI). 2. Aged between 18 and 60 years. 3. Undergoing regular maintenance pharmacotherapy. 4. Demonstrating a stable clinical condition for at least six months. 5. Presence of persistent negative symptoms. 6. Han ethnicity. 7. Completion of at least five years of formal education. 8. Right-handedness. 9. Normal vision and hearing (with or without correction), and absence of any language communication disorders.
Exclusion criteria
Exclusion criteria: 1. A history of organic brain disease, traumatic brain injury, endocrine disorders, or abnormal laboratory findings related to blood, cardiac, hepatic, or renal function upon examination. 2. A history of intellectual disability or substance dependence, including alcohol and drug abuse. 3. Pregnant or lactating women. 4. Presence of contraindications to MRI scanning, such as the implantation of electronic or metallic devices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative symptoms in schizophrenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurocognitive symptoms in schizophrenia;Neuroimaging;socio-demographic characteristics;Plasma exosomes;Molecular genetic marker testing; | — |
Countries
China
Contacts
Public ContactZhu Tong
The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University
Outcome results
None listed