Intrauterine lesions that require hysteroscopic surgery
Conditions
Interventions
Control Group:Oliceridine not used.
Experimental Group:Oliceridine 1 mg:Oliceridine 1 mg Combined with Esketamine
Experimental Group:Oliceridine 2mg:Oliceridine 2 mg Combined with Esketamine
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
Female
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective hysteroscopic surgery under intravenous anesthesia; 2. Aged 30 to 65 years; 3.BMI 18–28 kg/m^2; 4.American Society of Anesthesiologists(ASA)physical status classification of I–II; 5. Patients who voluntarily participate and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of severe cardiovascular,cerebrovascular,pulmonary,hepatic,renal,or metabolic diseases; 2.Hypertension(systolic blood pressure>180 mmHg)or hypotension(systolic blood pressure1 hour; 9.Emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median effective dose(ED50)of esketamine.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The MOAAS score at 2 hours postoperatively;The MOAAS score at 6 hours postoperatively;Postoperative complications;Propofol dosage;Awakening time; | — |
Countries
China
Contacts
Public ContactJiafeng Wang
Shanghai Changhai Hospital
Outcome results
None listed