Skip to content

A multi-omics-based study of the bacterial flora mechanisms influencing differences in response to stauroschizumab in patients with moderate-to-severe psoriasis

A multi-omics-based study of the bacterial flora mechanisms influencing differences in response to stauroschizumab in patients with moderate-to-severe psoriasis

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500101048
Enrollment
Unknown
Registered
2025-04-18
Start date
2025-04-30
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psoriasis

Interventions

Observation group:None

Sponsors

Shenzhen Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Voluntarily sign the informed consent form 2. Adult patients aged 18 to 75 3. Patients who have been diagnosed with psoriasis in accordance with the "Chinese Psoriasis Diagnosis and Treatment Guidelines 2018" and are required to receive secukinumab treatment as judged by their treating doctors.

Exclusion criteria

Exclusion criteria: 1. Previously, biological agents have been used for psoriasis treatment; There was an active infection within 2 weeks before treatment, or a history of persistent, chronic or recurrent infection; A history of malignant diseases within the past five years (excluding basal cell carcinoma or photogenic keratosis, cervical cancer in situ or non-invasive malignant colonic polyps) and pregnancy. 2. The patient has erythrodermic psoriasis, generalized or localized pustular psoriasis, drug-induced or drug-induced severe psoriasis, or newly developed guttate psoriasis (or any other active skin disease). 3. The researcher determines that it is not suitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
Blood routine index;Microbiological indicator;Psoriasis area and severity index, PASI;

Secondary

MeasureTime frame
TNF-a;IL-17;

Countries

China

Contacts

Public ContactDeng Quanwen

Shenzhen Hospital of Southern Medical University

xueman0623@163.com+86 198 2960 5490

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026