Neurocognitive dysfunction after general anesthesia and surgery
Conditions
Interventions
Patient group:None
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Gender not limited, age >= 18 years old, BMI 18-29 kg/m^2; 2.ASA II-IV grade, NYHA heart function II-IV grade; 3.Patients who undergo elective third level or higher surgeries; 4.The patient currently has the ability to live independently; 5.The patient agrees to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Existing history of neurological (acute or chronic), psychiatric or clinically significant neurovascular disease, cerebrovascular disease or neurosurgical surgery; 2.Patients who have recently or are currently receiving anti-inflammatory drug treatment and have a history of alcohol or drug abuse; 3.Patients with severe organ failure (such as heart, kidney, or liver) and severe liver or kidney dysfunction; 4.Patients with coagulation disease, poor control of diabetes or autoimmune disease; 5.Use a simple mental state examination for preoperative screening to exclude patients with mild cognitive impairment (defined as scores below 24); 6.Patients with limited vision, hearing, or motor function who cannot cooperate or refuse follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive status;Symbol digit modalities Test (SDMT);Digit span test (DST);Auditory verbal learning test (AVLT);Shape trails test;Color word test;Acetylated tau;Total Tau;Phospho-tau;p300/CBP acetyltransferase;Sirtuin1 deacetylase; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia duration;Surgical duration;Cardiopulmonary bypass duration;Aortic cross-clamp duration;Gender;Age;Body Mass Index;ASA classification;Educational level;Diabetes;hypertension;Blood loss;Postoperative ICU residency duration;Duration of hypothermia;Intraoperative blood gas analysis; | — |
Countries
China
Contacts
Public ContactQinxue Dai
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed