Hypoxic-ischemic lung injury caused by unilateral ventilation
Conditions
Interventions
Experimental group:Intravenous administration of dexmedetomidine
Sponsors
Civil Aviation General Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with malignant lung cancer diagnosed by thoracic surgery and scheduled for lobectomy, segmentectomy, or wedge resection of the lung. 2. Aged 30-75 years old; 3. ASA Levels II-III; 4. Single lung ventilation time: 1-3 hours; 5. 18.5 < BMI < 23.9; 6. Sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Patients who undergo total lung resection, emergency thoracotomy, mechanical ventilation without tube removal after surgery, recent use of antioxidants (such as vitamin E supplements), severe co-existing medical conditions or complications, etc. 2. The researchers believe that there are other factors that make some participants unsuitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Antioxidant Capacity (TAS) of Peripheral Blood;Peripheral Blood Mitochondrial DNA (mtDNA) Copy Number;The level of glutathione peroxidase 4 (GPX4) protein in Bronchoalveolar lavage fluid macrophages;Oxidative Stress Index (OSI);Peripheral blood glutathione peroxidase 4 (GPX4);Concentration of Fe2+ in alveolar macrophages in bronchoalveolar lavage fluid;The concentration of malondialdehyde (MDA) in alveolar lavage fluid macrophages;Total Oxidative State of Peripheral Blood (TOS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Percutaneous arterial oxygen saturation;Heart rate;Mean arterial pressure,MAP;The time of one-lung ventilation;Quality of life scale for lung cancer; | — |
Countries
China
Contacts
Public ContactLihua Du
Civil Aviation General Hospital
Outcome results
None listed