Coronary Artery Disease Coronary Microvascular Disease
Conditions
Interventions
The group of patients with confirmed coronary heart disease. (Perform myocardial perfusion imaging and 18F-FDG PET/CT myocardial metabolic imaging):NA
The group of patients with clinically suspected coronary microvascular disease (Perform rest and stress 13N-NH3 PET/CT myocardial perfusion imaging):NA
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Participants have provided signed informed consent and expressed willingness to comply with the entire study protocol. 2. Patients aged 18-75 years old, gender is not limited. 3. Patients with clinically suspected coronary microangiopathy, patients with symptoms such as panic, chest pain and chest tightness, and morphological imaging (coronary CT angiography or coronary angiography) is negative or positive but not consistent with symptoms; or patients with clinically confirmed coronary artery disease; 4. Patients who have recent results of electrocardiogram, echocardiogram with cardiac enzymes; 5. Patients consent to undergo myocardial imaging via long-axis ultra-high-resolution PET/CT and are deemed physically capable of tolerating the procedure.
Exclusion criteria
Exclusion criteria: 1. Allergic to the load drugs and tracers used in PET/CT scans. 2. Suffering from severe liver or kidney insufficiency, cardiopulmonary failure, or other serious comorbidities. 3. Pregnant or breastfeeding women. 4. Patients deemed unsuitable for participation in the clinical trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Image quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| absolute myocardial blood flow;area of scarred myocardium;coronary flow reserve;area of viable myocardium; | — |
Countries
China
Contacts
Public ContactXiaoli Lan
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed