Perioperative neurocognitive disorders (PND)
Conditions
Interventions
Case series:None
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Subjects voluntarily participate in the study and sign an informed consent form; 2. Age >= 60 years; 3. Scheduled for elective unilateral lower limb joint replacement surgery (hip or knee joint); 4. Expected duration of anesthesia exceeds 2 hours;
Exclusion criteria
Exclusion criteria: 1. Subjects with severe central nervous system or psychiatric disorders that prevent cooperation with scale assessments (e.g., speech impairment or inability to write due to sequelae of cerebral infarction); 2. Mini-Mental State Examination (MMSE) scores below the required threshold (illiterate <17; primary school <20; middle school and above <24); 3. Severe visual or hearing impairments, or color blindness/color weakness; 4. Alcohol or drug dependence; 5. Severe diseases, such as severe liver dysfunction (Child-Pugh class C), severe renal dysfunction (end-stage renal disease requiring replacement therapy), or ASA classification IV; 6. Recent use of sedatives or antidepressants; 7. Patients undergoing emergency surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PND at 1 week postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function assessment results at 1 month;The difference in score changes between the PND group and the non-PND group for each scale preoperatively and postoperatively;The cognitive function assessment results one year post-surgery;The time to first ambulation after surgery;Area under the receiver operating characteristic curve;Sensitivity;Specificity;Brier Score;Decision curve analysis; | — |
Countries
China
Contacts
Public ContactZhiheng Liu
Shenzhen Second People's Hospital
Outcome results
None listed