Postoperative Delirium
Conditions
Interventions
Lidocaine group:Before induction, a loading dose of lidocaine of 1.5mg/kg was given within 15 min, and during the maintenance period, lidocaine was pumped intravenously at a rate of 1.5mg/kg/h until t
Control group:Before induction, the control group was given the same volume of normal saline within 15 minutes, and the same volume and speed of normal saline was pumped intravenously during the maint
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) grade ?-?; (2) age of 65-90 years old; (3) patients undergoing elective laparoscopic radical resection of colorectal cancer.
Exclusion criteria
Exclusion criteria: (1) preoperative mental disorder, cognitive dysfunction or communication difficulties; (2) obvious sinus bradycardia (heart rate <50 beats/min) or other serious cardiovascular diseases; (3) symptomatic cerebrovascular disease (such as previous stroke); (4) history of liver and kidney dysfunction; (5) lidocaine allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum inflammatory markers: high mobility group box 1 (HMGB1), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) concentrations;Severity of Delirium;Time of Onset of Delirium;Duration of Delirium;VAS Score on Postoperative Days 1 to 7;Number of PCIA Demands within 24 Hours Postoperatively;Cumulative Opioid Consumption via PCIA within 24 Hours;Perioperative Adverse Events; | — |
Countries
China
Contacts
Public ContactZhang Wenjie
The First Hospital of Shanxi Medical University
Outcome results
None listed