Hypotension
Conditions
Interventions
Case series:fospropofol disodium (modified Dixon sequential method)+ sufentanil
Sponsors
Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1 Age: 65 to 90 years old, regardless of gender; 2 Patients scheduled for elective surgery under general anesthesia with single-lumen endotracheal intubation; 3 ASA (American Society of Anesthesiologists) physical status classification I or II; 4 18 kg/m^2 < BMI < 30 kg/m^2; 5 Fully comprehend the study protocol, voluntarily participate, and provide personally signed informed consent.
Exclusion criteria
Exclusion criteria: 1 Patients not receiving standardized antihypertensive therapy or with poorly controlled blood pressure (systolic blood pressure >= 160 mmHg or = 100 mmHg); 2 Heart rate (HR) 120 bpm; 3 Uncontrolled diabetes mellitus or coronary heart disease; 4 Severe hepatic/renal dysfunction (Child-Pugh score >7, estimated glomerular filtration rate [eGFR] <30 mL/min/1.73m^2); 5 Anticipated difficult airway; 6 History of allergic diseases or hypersensitivity to the investigational drugs; 7 Family history of malignant hyperthermia; 8 Untreated or uncontrolled hyperthyroidism; 9 Participation in other drug clinical trials within the preceding 3 months; 10 Pregnancy, lactation, or intention to conceive within 1 month postoperatively; 11 History of alcoholism or substance abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endotracheal intubation response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Saturation of Peripheral Oxygen ;The injection pain; | — |
Countries
China
Contacts
Public ContactLin Xiaofen
Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed