Burn(s),Burn pain,Procedural pain,Acute pain
Conditions
Interventions
SKET-0.1 group:Dexmedetomidine continuous infusion at 60 mL/h + esketamine 0.1 mg/kg IV bolus
SKET-0.5 group:Dexmedetomidine continuous infusion at 60 mL/h + esketamine 0.5 mg/kg IV bolus
SKET-0.3 group:Dexmedetomidine continuous infusion at 60 mL/h + esketamine 0.3 mg/kg IV bolus
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 6 Years
Inclusion criteria
Inclusion criteria: 1.The burn surgery department plans to perform wound dressing change for the pediatric burn patient. 2.Children aged 1–6 years (both sexes eligible). 3.BMI >= -3 SD and < +3 SD; 4.Burn severity: Mild to severe, defined as total burn area = 25% TBSA (Total Body Surface Area) or third-degree burns <= 10% TBSA. 5.No significant underlying diseases, with ASA (American Society of Anesthesiologists) Physical Status Classification of I-II. 6.The parents or legal guardians are fully informed and have consented to participate in the entire research process.
Exclusion criteria
Exclusion criteria: 1.Pediatric patients currently on sedative medication; 2.Children with a history of asthma; 3.Patients with third-degree (full-thickness) burns involving the head and face; 4.Pediatric patients with extensive burns complicated by severe infection/shock, or those currently presenting with upper respiratory tract infections; 5.Pediatric patients with inhalation lung injury requiring mechanical ventilation or tracheostomy; 6.Pediatric patients with hypersensitivity to any investigational drug(s); 7.Pediatric patients with severe organ dysfunction (e.g., heart failure/severe hepatic or renal insufficiency) and unstable vital signs; 8.Parents or legal guardians of the pediatric patient declined to provide informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Face, Legs, Activity, Cry, Consolability Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve medium-depth sedation after esketamine administration;vital signs;UMSS scale;Cry,Facial,Child Verbal,Torso,Touch,Legs Scale;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactSong Xiaoxing
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed