Skip to content

A national multicenter study of pIgR antibody as a novel serum marker for the diagnosis of primary biliary cholangitis (PBC)

A national multicenter study of pIgR antibody as a novel serum marker for the diagnosis of primary biliary cholangitis (PBC)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500100998
Enrollment
Unknown
Registered
2025-04-17
Start date
2025-04-25
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with elevated ALP and/or GGT levels before the visit but with unknown causes of liver injury

Interventions

Gold Standard:The gold standard is the recommended standard of the guidelines. The gold standard was determined according to the guidelines for the diagnosis and treatment of primary biliary cholangit
(2) Positive for AMA/AMA-M2, or other PBC-specific autoantibodies (anti-gp210 antibody, anti-sp100 antibody)
(3) Histological evidence of non-purulent destructive cholangitis and small bile duct destruction.
Index test:According to the needs of the patients diagnosis and treatment, the investigator will conduct physical examination, medical history collection and various examinations, including abdominal

Sponsors

The First Affiliated Hospital of Army Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Age 18 years or older, gender is not limited; 2) patients with elevated ALP and/or GGT for unspecified causes of liver impairment; 3) Complete relevant clinical data; 4) The patient is informed of the study content and voluntarily signs the study consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with diseases of kidney, heart, blood and other organs; 2. Patients with human immunodeficiency virus infection; 3. Pregnant or lactating women; 4. Patients with tumors.

Design outcomes

Primary

MeasureTime frame
pIgR antibody;

Countries

China

Contacts

Public ContactChai Jin

The First Affiliated Hospital of Army Medical University

jin.chai@cldcsw.org+86 13996402074

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026