Age-related dry eye
Conditions
Interventions
Dry eye treatment group:Twenty subjects with age-related dry eye were given sodium hyaluronate eye drops four times a day, 1-2 drops each time, applied to the eyelids. Take chrysanthemum granules in c
Dry eye contral group:Twenty subjects with age-related dry eye were given sodium hyaluronate eye drops to the affected eyes, 4 times a day, 1-2 drops each time, applied to the eyelids, and continuousl
Youth group without dry eye:None
Elderly group without dry eye:None
Sponsors
The First Hospital of Hunan University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for young people without dry eyes (1) When signing the informed consent form, the age range is 18-30 years old (including 18 and 30 years old), and there is no gender limit; (2) Prior to conducting any research related procedures, an informed consent form must be signed; (3) Excluding dry eyes, there are no other eye diseases; (4) Good compliance, capable of completing this study; (5) According to the researchers' assessment, the anatomical structure of the eyelids is normal. (6) Testosterone in the blood is at normal levels. Inclusion criteria for elderly people without dry eyes (1) When signing the informed consent form, the age range is 60-80 years old (including 60 and 80 years old), and there is no gender restriction; (2) Prior to conducting any research related procedures, an informed consent form must be signed; (3) Excluding dry eyes, there are no other eye diseases; (4) Good compliance, capable of completing this study; (5) According to the researchers' assessment, the anatomical structure of the eyelids is normal; (6) Testosterone in the blood is at normal levels. Inclusion criteria for age-related dry eye population (1) When signing the informed consent form, the age range is 60-80 years old (including 60 and 80 years old), and there is no gender restriction; (2) Prior to conducting any research related procedures, an informed consent form must be signed; (3) Meets the diagnostic criteria for dry eye and has no comorbidities of other eye diseases; (4) Good compliance, capable of completing this study; (5) There are no systemic diseases such as Sjogren's syndrome or Steven Johnson syndrome that can cause dry eye; (6) According to the researchers' assessment, the anatomical structure of the eyelids is normal; (7) Testosterone levels in the blood are lower than normal.
Exclusion criteria
Exclusion criteria: (1) Long eye axis (>26mm) and short eye axis (-6.0D; (2) Abnormal anterior segment examination (including closed corner examination); (3) History of other organic eye diseases and systemic corticosteroid use; (4) Individuals with a history of eye surgery or planning to undergo surgical treatment during the study period; (5) Either eye has a history of poorly controlled glaucoma, or either eye is receiving eye drops for glaucoma treatment; (6) There are serious systemic diseases, such as uncontrollable hypertension, diabetes, etc; (7) Have a known history of drug dependence, drug abuse, or drug use within the past 5 years; (8) Patients who are unable to use the investigational drug as required; (9) Participants in other clinical trials within 3 months prior to the start of this trial; (10) Researchers believe that participants are not suitable for the trial due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum protein composition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum metabolites composition;Protein components of tears;Metabolites in tears;Schirmer test ;Break-up time(BUT);Corneal fluorescence staining; | — |
Countries
China
Contacts
Public ContactXiaolei Yao
The First Hospital of Hunan University of Chinese Medicine
Outcome results
None listed