Sepsis
Conditions
Interventions
Time-restricted feeding group:Enteral feeding is performed daily from 5:00am to 5:00pm
Continuous feeding group:Feeding continued daily during the study period
Sponsors
Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old. 2. Meeting the diagnosis of sepsis, with the diagnostic criteria following the latest "Sepsis-3.0" standards established by the American College of Critical Care Medicine in 2016. 3. Anticipated mechanical ventilation for more than 72 hours (assessed by senior clinical doctors in the ICU). 4. Anticipated ICU stay of at least 7 days (assessed by senior clinical doctors in the ICU). 5. Sequential Organ Failure Assessment (SOFA) score >= 2. 6. Requiring nasogastric tube enteral nutrition. 7. Voluntarily participating in this study and signing the informed consent form. If the subject is unable to read and sign the informed consent form due to incapacity or other reasons, their legal guardian must act on their behalf in the informed consent process and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe liver dysfunction/liver failure (Child-Pugh score > 7 points / Class B). 2. Chronic kidney disease stage 5 (KDIGO stage 5). 3. Total pancreatectomy/insulin-dependent diabetes mellitus (IDDM). 4. Severe metabolic disorders (hospitalized for diabetic hyperosmolar coma/ketosis acidosis). 5. Refractory shock (norepinephrine infusion rate > 0.2 µg/kg/min, expected to deteriorate or die within 48 hours). 6. Patients requiring extracorporeal membrane oxygenation (ECMO) support. 7. Patients requiring hormone replacement therapy. 8. Contraindications to enteral nutrition or those who have received enteral nutrition for >= 12 hours before randomization. 9. Patients who refuse invasive rescue or those transferred from other ICUs. 10. Pregnant or lactating women. Vulnerable groups other than critically ill patients, including those with mental illness, cognitive impairment, illiteracy, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Beta-hydroxybutyric acid levels; | — |
Countries
China
Contacts
Public ContactWang Qianwen
Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed