depression
Conditions
Interventions
High Rumination Group:Aripiprazole + Escitalopram
High Rumination Group:Escitalopram
Healthy controls:none
lower Rumination Group:Conventional antidepressant treatment
Sponsors
The Second XIANGYA Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.Patients met the DSM-5 diagnostic criteria for Major Depressive Disorder (MDD) as determined by the MINI interview, and were excluded if they had any psychiatric comorbidities other than anxiety disorders. Patients were either drug-naïve for their first depressive episode or had a previous medication history but had not taken any psychotropic medication (excluding benzodiazepines) for at least six weeks prior to the study; 2. Currently in a depressive episode, with a score of >=21 on the 24-item Hamilton Depression Rating Scale (HAMD-24) and =61; Low-rumination group if RRS <61; 3. age 18-35 years (fewer factors affecting the dopamine system), gender is not limited; 4. Minimum education level of junior high school, with the ability to independently read and understand the informed consent form and self-report questionnaires; 5. Han ethnicity, right-handed; 6. The patient provided written informed consent after reading and understanding the purpose and procedures of the study. Healthy Controls Inclusion Criteria: Participation is permitted if the answer to all of the following statements is "Yes": 1. No psychiatric disorder was identified based on the MINI interview; 2. Does not meet the diagnostic criteria for depressive disorder, and currently scores <=7 on the 24-item Hamilton Depression Rating Scale (HAMD-24) and <=5 on the Young Mania Rating Scale (YMRS); 3. age 18-35 years (fewer factors affecting the dopamine system), gender is not limited; 4.Minimum education level of junior high school, with the ability to independently read and understand the informed consent form and self-report questionnaires; 5.Han ethnicity, right-handed; 6. The individual has read the informed consent form and agrees to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Meets the DSM-5 diagnostic criteria for psychiatric disorders, excluding anxiety disorders; 2. Depressive disorder with psychotic features; 3. Presence of severe suicidal ideation or suicidal behaviors; 4. History of traumatic brain injury or coma; 5. Presence of organic brain disorders or severe physical illnesses (e.g., thyroid disorders, systemic lupus erythematosus, diabetes, infections, major trauma, etc.); 6. Equipped with a cardiac pacemaker or non-removable metal implants in the body; 7. History of alcohol or substance dependence; 8. Pregnant or lactating women; 9. History of epileptic seizures or a family history of epilepsy; 10: Underwent non-pharmacological treatments (e.g., ECT, rTMS, psychotherapy, etc.) within the past six months. Healthy controls: 1. Meets the DSM-5 diagnostic criteria for psychiatric disorders; 2. History of head trauma or coma; 3. Presence of organic brain disorders or severe physical illnesses (e.g., thyroid disorders, systemic lupus erythematosus, diabetes, infections, major trauma, etc.); 4. Equipped with a cardiac pacemaker or non-removable metal implants; 5. History of alcohol or substance dependence; 6. Pregnant or lactating women; 7. History of epileptic seizures or a family history of epilepsy; 8. Underwent non-pharmacological treatments (e.g., ECT, rTMS, psychotherapy, etc.) within the past six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depression;rumination;Dopamine D2 receptor availability;anxiety;Neurocognitive measurement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive Emotion Regulation Questionnaire;Young manic rating scale;Treatment Emergent Symptom Scale;eye tracking assessment;Magnetic resonance spectroscopy (MRS) of the anterior cingulate cortex (ACC); | — |
Countries
China
Contacts
Public ContactYan Zhang
The Xiangya Second Hospital of Central South University
Outcome results
None listed