Postoperative delirium is an acute-onset, transient abnormality of brain function, most commonly occurring within 1 week of surgery, characterized by inattention, changes in the level of consciousness, and acute changes in cognitive function. There can be a variety of clinical manifestations, such as attention disorders, disturbed levels of consciousness, cognitive dysfunction, sleep-wake cycle di
Conditions
Interventions
Cgroup:No intervention
rTMS group:transcranial magnetic stimulation,TMS
Sponsors
The First Hospital Of Jiaxing
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The indication for surgery is degenerative joint disease or hip/knee fractures, confirmed by clinical assessment and imaging examinations; 2.Patients who underwent total hip arthroplasty (THA) or total knee arthroplasty (TKA) under general anesthesia. 3.All patients received general anesthesia via endotracheal intubation. 4.The patient age was=60 years. 5.Patients were classified as American Society of Anesthesiologists (ASA) physical status I to III. 6.Informed consent was obtained from all participants, and written consent forms were duly signed. 7.The patient Montreal Cognitive Assessment(MoCA)=26 scores and able to communicate effectively.
Exclusion criteria
Exclusion criteria: 1.The patient had pre-existing risk factors for postoperative delirium (POD), such as a history of other neurological or psychiatric conditions, dementia, alcohol abuse, cranial/scalp damage, or documented epilepsy. 2.The patient had a metallic implant, such as a pacemaker, in situ. 3.History of head trauma such as intracranial hemorrhage. 4.Serious cerebrovascular diseases such as brain tumors. 5.The patient refused to sign the informed consent form. 6.The participant used concomitant medications or therapies that could affect the trial's outcome measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hematological Parameters;Frailty score;Sleep quality score;Postoperative Pain;Preoperative anxiety score;(the severity of POD);(the subtype of POD);Postoperative dosage of opioid drugs; | — |
Countries
China
Contacts
Public ContactZijun,Zhao
The First Hospital Of Jiaxing
Outcome results
None listed