Postoperative pain after colorectal cancer surgery
Conditions
Interventions
The group of Fospropofol disodium (Group F):Sufentanil 0.3 µg/kg was intravenously injected, and propofol disodium phosphate was diluted to 20 ml at a concentration of 10 mg/kg for intravenous infusi
Propofol group (Group P):Sufentanil was administered intravenously at a dose of 0.3 µg/kg, and propofol was diluted to 20 ml by a concentration of 2 mg/kg for intravenous infusion.
Sponsors
The Affiated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years old, gender not limited; 2.Scheduled for elective laparoscopic radical resection of colorectal cancer; 3.ASA classification II-III; 4 Preoperative Mini-Mental State Examination (MMSE) score >= 24 points; 5.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular and cerebrovascular diseases (such as NYHA classification >= III grade or LVEF = 160/100 mmHg); acute coronary syndrome or stroke occurred within 6 months); 2.Abnormal liver and kidney functions (ALT/AST > 2 times upper limit, eGFR 7.5%); 4.Long-term use of sedatives/anxiolytic drugs before surgery (> 1 month); 5.History of dementia or mental illness; 6.Allergy to propofol or soybean/eggs; 7.More than 1 intubation or intubation time > 30 seconds; 8.Surgery time 4 hours, intraoperative blood loss > 15 ml/kg or intraoperative blood transfusion; 9.Postoperative admission to ICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular hemodynamic indicators at each time point during the induction period;Montreal Cognitive Assessment Scale MoCA-Basic;Confusion Assessment Method Scale;The incidence of hypotension during general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of awakening and occurrence of postoperative complications; | — |
Countries
China
Contacts
Public ContactWan Qing
The Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed